Simon Crosby Sr. was born about 1608 in Holme-on-Spalding-Moor, co. York, England. In Apr 1635, he arrived in Cambridge, Middlesex Co., Massachusetts on board the "Susan and Ellen". He took the oath of freeman on 3 Mar 1635/36. He died in Sep 1639 in Cambridge, Middlesex Co., Massachusetts. He was a husbandman. He was married to Anne Brigham on 21 Apr 1634 in Holme-on-Spalding-Moor, co. York, England.

Anne Brigham was born about 1606 in Holme-on-Spalding-Moor, co. York, England. She died on 11 Oct 1675 in Braintree, Norfolk Co., Massachusetts. She was buried in Old Hancock burying ground, Quincy, Norfolk Co., Massachusetts. Children were:

i. Rev. Thomas Crosby was born about 1634/35 in England. He was baptized on 26 Feb 1634/35 in Holme-on-Spalding-Moor, co. York, England. He graduated in 1653 from Harvard College. He died on 13 Jun 1702 in Boston, Suffolk Co., Massachusetts.
ii. Simon Crosby Jr..
iii. Joseph Crosby was born in Feb 1638/39 in Cambridge, Middlesex Co., Massachusetts. He died on 26 Nov 1695.

Anne Brigham married second about 1645 William Tompson.