Thomas Brigham was baptized on 21 May 1576 in Holme-on-Spalding-Moor, co. York, England. He died on 19 Mar 1633 in Holme-on-Spalding-Moor, co. York, England. He was married to Isabel Watson on 4 Feb 1600/1 in Holme-on-Spalding-Moor, co. York, England.

Isabel Watson was baptized on 21 Feb 1560/61 in Holme-on-Spalding-Moor, co. York, England. She was buried on 25 Jun 1634 in Holme-on-Spalding-Moor, co. York, England. Children were:

i. Constance Brigham.
ii. Thomas Brigham was born in 1603 in England. He died on 8 Dec 1653 in Cambridge, Middlesex Co., Massachusetts.
iii. Anne Brigham.