| | 5 May:
¡Happy Cinco de Mayo! |
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| 1521 | | 13 Aug:
Tenochtitlán falls to Cortés' conquistadors.KWWL npr |
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| 1777 | | 29 Nov:
The first pueblo in California is established as San Jose, or El Pueblo de San Jose de Guadelupe.SJPL SJ.gov |
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| 1821 | | 16 Nov:
The Santa Fe Trail opens for business.NPS SFT |
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| 1835 | |
| 1836 | | 23 Feb:
A group Texians and Tejanos fight to defend the Alamo against superior Mexican forces under General Santa Anna.TheAlamo UIW |
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| | 6 Mar:
The Alamo defenders are overwhelmed by Santa Anna's troops.TheAlamo LoC |
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| 1846 | |
| | 13 May:
President James K. Polk signs a declaration of war against Mexico.UVA USState |
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| | 14 Jun:
Anglo-Californians rebel against Mexican rule in the Bear Flag Revolt.BFM NPS |
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| 1847 | |
| | 9 Mar:
The American military attack the Mexican city of Veracruz.SotS UTA |
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| 1848 | |
| 1853 | |
| 1884 | | 13 Oct:
The Greenwich meridian is officially adopted globally as the prime meridian, the imaginary north-south line where the longitude is 0 degrees.W I R E D MAA |
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| 1897 | | 20 Aug:
World Mosquito Day marks the discovery of the malaria parasite.Mosquito EM |
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| 1916 | | 15 Mar:
General John Pershing leads an invasion of Mexico in pursuit of Pancho Villa.1stWW USArmy |
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| 1917 | |
| 1918 | | Feb:
The Spanish Flu pandemic kills at least 3% of the World's population.VLib npr |
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| | 27 Aug:
U. S. Army forces trade shots with Mexican troops and their German advisors in the only battle of World War I fought on American soil.BYU Tucson |
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| 1943 | | 20 Feb:
The Parícutin volcano begins to erupt in Parícutin, Mexico, marking the first time scientists are able to observe the complete life cycle of a volcano. SDSU SIArchives |
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| 1945 | | 24 Oct:
The United Nations is established.UN USState |
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| 1975 | | 2 Jan:
The Monarch butterfly's overwintering sites are discovered in the Mexican mountains by Ken Brugger and Catalina Aguado.TBR NWF |
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