Samuel Littlefield was baptized on 6 Aug 1710 in Wells, York Co., Province of Maine, Massachusetts. He was a farmer. He was married to Elizabeth Goodale on 1 Mar 1725.

Elizabeth Goodale was born on 28 Jul 1703 in Wells, York Co., Province of Maine, Massachusetts. Children were:

i. Phoebe Littlefield was baptized on 20 Feb 1726.
ii. Samuel Littlefield was baptized on 28 May 1727.
iii. Elizabeth Littlefield was baptized on 16 Nov 1729.
iv. Dependence Littlefield was baptized on 9 Apr 1732. He died before 10 Jun 1806.
v. Dorothy Littlefield was baptized on 30 Jun 1734. She died after 1771.
vi. Daniel Littlefield was baptized on 1 Aug 1736.
vii. Stephen Littlefield.

Samuel Littlefield married second, Sarah Wiggin, on 13 Mar 1746 in Wells, York Co., Province of Maine, Massachusetts.